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436,690,691,692 Under HG induced-kidney, SIRT1 and PGC-1 are downregulated, which exacerbates oxidative stress, activates mitochondrial apoptosis pathway, and impairs mitochondrial function, while resveratrol can partially offset these phenomena through the SIRT1/PGC-1a axis

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Adrian S, Scherzinger A, Sanyal A, et al